The History of Androstene
Systematic name: Androst-4-ene-3,17-dione
Molecular formula: C19H26O2
A lot of people have
been ranting about androstenedione for quite some time now. Anyway,
here is the story behind this new buzzword in the supplement market.
synthesized in 1935. A year later Dr. Charles Kochakian discovered
that androstenedione had both androgenic and anabolic effects. These
effects however, were only significant in castrated dogs, and even
then much weaker than the effects of testosterone. In 1962, a couple
of scientists gave normal women either 100-mg of DHEA or 100-mg of
androstenedione. The doses were mismatched for both bioavailability
and known biological activity, but both hormones increased
testosterone levels to six times above normal. However, the increase
in testosterone lasted only for about two hours and the peak level for
only a few minutes. In another study, referred to in the German patent
application form (read more further down), two groups of men were
given either 50 or 100-mg of androstenedione. With the lower dosage
the testosterone levels increased by 211% and with the higher dosage
up to 237%.
The story begins in
former East Germany
The research and
development of effective chemical drugs was once a huge industry in
East Germany. In the 70's, East German scientists begun to develop
androstenedione as an adjunct to testosterone-based anabolic steroids.
Androstenedione was in one way more interesting than most of the other
drugs because of the difficulty to find traces of it in drug tests. In
just a few days all signs of any abuse were gone, yet the effects met
up to satisfactory.
The East German scientists developed androstenedione to be taken
nasally similar to taking common nasal spray. By taking it this way,
they achieved the fastest effect possibly and at the same time, it
would be out of the system in "no time". The interesting
part is that they used it as a "mental performance booster",
and not to build muscle or strength. Powerhouse Supplements only
provides top quality articles and supplements.
Androstenedione is a
direct hormone precursor of testosterone and is chemically classified
as an androgen. It's found in humans, animals and many plants. It's
produced in all mammals by the gonads and the adrenal glands.
Androstenedione disrupts the balance between testosterone and
epitestosterone in the same way as other testosterone-related drugs
do. It will raise your testosterone/epitestosterone ratio from 2-3:1
to about 14:1, which will make you test positive in a drug control.
(The Olympic Committee allows a ratio up to 6:1) Androstenedione has
no muscle building effects on its own; it has to be converted to
testosterone by the liver in order to produce any effect. You'll also
have to consider the facts that your testosterone levels has to be
elevated for a longer period of time for any muscle mass gains to
occur. The question is if a two hours elevation of testosterone levels
is enough. Contact an ISSA or Parrillo Certified Personal Trainer at
Powerhouse Supplements for additional information on products,
articles, nutrition, or training.
If you decide to use
Androstene - what you should know
Common side effects
related to elevated testosterone levels are for example, gland
enlargement, gland cancer, hair loss, water retention, lower LDL
levels, impotence, acne and lower production of testosterone. Some of
these side effects are in relation to the rate of transformation of
testosterone to estrogen. Especially women should avoid elevated
testosterone levels because they could lead to lasting changes such
as, deep voice, beard, enlargement of genitals, and male lineament.
These effects are permanent! Women should not use androstenedione and
males should be aware of the risks. However, if you use the
recommended dosages, the risk of any severe side effect should be
minimal. It's recommended to take 100-mg once every day before your
workouts for four weeks. You should also consider taking antioxidants
like vitamin E while taking androstenedione. This might be a good idea
since androstenedione increases the production of free radicals, which
might lead to cell damage. Younger people that are still growing
should not take androstenedione because elevated androgen-levels may
stop their natural skeletal growth.
Note: In the US Androstene is against the law and no longer legal to buy or use.